Why astronauts are susceptible to common infections

Washington, February 5 (ANI): Researchers have found that living in space weakens astronauts' immune systems.

The findings are providing clues on how to tackle diseases on Earth before symptoms appear.

Ever since the first humans ventured into space we have known that astronauts can suffer from common infections that would be quickly dealt with by healthy people on Earth.

Until now, it was not clear what was blocking astronauts' immune systems from working normally.

In 2006, ESA astronaut Thomas Reiter performed an experiment on the International Space Station using ESA's Kubik space incubator. A batch of human immune cells was allowed to float in microgravity while another was held in a centrifuge to simulate gravity. The cells were preserved for analysis back on Earth.

The cells that experienced simulated gravity as if on Earth were found to be in good health compared to their weightless equivalents.

By comparing the samples, investigators saw what was stopping the immune cells from working properly. A specific transmitter in the immune cells, called the Rel/NF-?B pathway, stops working in weightlessness.

"Normally, when our bodies sense an invasion, a cascade of reactions occur that are controlled by the information held in our genes, similar to an instruction book," explained Isabelle Walther, an investigator based in Zurich, Switzerland.

"Finding which gene does what is like looking for the right key to fit a keyhole, without having found the keyhole yet," she stated.

Studying cells that have flown on the International Space Station is putting researchers on the right path to finding the key to how our immune system works. Comparing samples is showing them where to look to find which genes instruct our immune cells to react to diseases, and how.

"We are working towards a finer control of disease," said Millie Hughes-Fulford, NASA astronaut and a investigator on this experiment.

This research could help to tackle two types of disease. Stopping genes that activate our immune system would help to relieve people suffering from autoimmune diseases such as arthritis. The pharmaceutical industry could find the genes that need be active to fight specific illnesses and market tailored antibodies. (ANI)

Matches

MORE TOP STORIES TODAY

Royal test for Kings

Royal test for Kings

Preview — Clash of philosophies between Australia-centric teams More »

Have nothing to prove to anybody — Sehwag

Have nothing to prove to anybody — Sehwag

The Nawab of Najafgarh says a good run in IPL could help his chances of a comeback on India's tour to England in June. More »

Duminy steals first win for Delhi

Duminy steals first win for Delhi

Furious fifties by Duminy and Dinesh Karthik end a long losing streak for the Daredevils. More »

Five things England must do to bounce back

Five things England must do to bounce back

England have appointed a new head coach in Peter Moores. More »

AB, Parthiv seal Bangalore's second win

AB, Parthiv seal Bangalore's second win

Royal Challengers overcame a stutter to cruise to the small target they were set by Mumbai Indians. More »

‘Felt like helpless minority’

‘Felt like helpless minority’

Former BCCI treasurer Ajay Shirke says emotions got the better of the Srinivasan and he tried to oversimplify things by calling Meiyappan an “enthusia… More »

No way back for Pietersen: ECB

No way back for Pietersen: ECB

Kevin Pietersen's hopes of reviving his international career appeared to end Saturday when ECB managing director Paul Downton said there was 'no way back'… More »

The world record that nearly wasn't

The world record that nearly wasn't

Twenty years ago this week, Brian Lara became Test cricket's highest scorer, but he almost didn't make it. More »

Srinivasan can attend BCCI meeting

Srinivasan can attend BCCI meeting

His status as president of TNCA makes him eligible to attend the Working Committee meeting on Sunday. More »

Moores gets second stint as coach

Moores gets second stint as coach

In a two-year spell from 2007 to 2009, the 51-year-old Moores led England in seven Test series. More »

Bangladesh senior players to see shrink

Bangladesh senior players to see shrink

Bangladesh's senior players will have three sessions with a psychological skill development coach later this month More »

Maxwell carves his parallel universe

Maxwell carves his parallel universe

Glenn Maxwell seems to project an icy disdain when at the crease. Match situations rarely faze him and the bubble in which he plays excludes everyone … More »

BCCI is not anybody’s property — Dalmiya

BCCI is not anybody’s property — Dalmiya

Dalmiya feels that Srinivasan’s ‘power hungry’ attitude isn’t helping matters. More »

Tough for bowlers: Saeed Ajmal

Tough for bowlers: Saeed Ajmal

The 36-year-old believes the T20 format and rule changes in 50-over matches have made a real difference. More »

KP ridicules idea of day-night Tests

KP ridicules idea of day-night Tests

Kevin Pietersen has ridiculed the idea of day-night Test cricket, saying the game would be so different to proper Test cricket that we will need a whole… More »

Rajasthan edge low-scoring thriller

Rajasthan edge low-scoring thriller

The bowlers restricted Hyderabad to 133 for 6 before Rahane and Binny took Rajasthan over the line. More »

Maxwell blitz takes Punjab home

Maxwell blitz takes Punjab home

The Kings XI batsman blasted a 43-ball 95 to help his team pull off a massive chase against Chennai Super Kings. More »

BCCI members want independent probe

BCCI members want independent probe

The board members are realising after the Supreme Court's observations that something has to be done — IS Bindra More »

'BCCI lacks leaders to take on Srini'

'BCCI lacks leaders to take on Srini'

Two former BCCI presidents, Shashank Manohar and Jagmohan Dalmiya, have reacted strongly to the news of the BCCI calling an emergent meeting on Sunday… More »

Delhi look for first points against confident Kolkata

Delhi look for first points against confident Kolkata

Preview — The threat of Sunil Narine looms large again. More »

Bangalore vs Mumbai: A battle of the big-hitters

Bangalore vs Mumbai: A battle of the big-hitters

Preview — Given the firepower in both line-ups, Dubai crowd may see another high-scorer More »

Yuvraj tees off to Sharjah's delight

Yuvraj tees off to Sharjah's delight

Yuvraj Singh was hardly convincing to begin with against Delhi, but a big dose of crowd support and a helping of poor bowling meant he had the opportunity… More »

Stressed Trott stands down again

Stressed Trott stands down again

The England and Wales Cricket Board (ECB) on Friday confirmed that batsman Jonathan Trott is to take another break from all cricket with immediate eff… More »

PCB starts another coach hunt

PCB starts another coach hunt

The PCB has decided to not extend the contracts of head coach Moin Khan, fielding coach Shoaib Mohammad and batting consultant Zaheer Abbas, and has invited… More »