Sedentary behaviour linked to precancerous colorectal tumours' recurrence

Washington, Oct. 30 (ANI): Men spending most of their time engaged in sedentary behaviours are at highest risk for recurrence of colorectal adenomas, benign tumours that are known precursors of colorectal cancers, according to a study.

Christine L. Sardo Molmenti, PhD, MPH, postdoctoral research fellow in the Department of Epidemiology at Columbia University Mailman School of Public Health in New York, said that sedentary behaviour is emerging as a risk factor for poor health.

Sardo Molmenti and colleagues performed a pooled analysis of participants of two randomized, double-blind, placebo-controlled phase III clinical trials conducted at the University of Arizona Cancer Center in Tucson and the Mel and Enid Zuckerman College of Public Health: The Wheat Bran Fiber Study and the Ursodeoxycholic Acid Trial.

All participants in the trials had one or more colorectal adenomas removed during a colonoscopy conducted in the six months prior to their trial enrollment.

Among the participants were 1,730 who had completed a self-administered questionnaire that included questions about leisure, recreational, household, and other categories of activity at enrollment, and had undergone a follow-up colonoscopy.

When researchers examined the data for men and women separately, they found that men who reported spending more than 11.38 hours a day engaged in sedentary behaviours, such as writing, typing or working on a computer, and reading, were 45 percent more likely to experience colorectal adenoma recurrence compared with men who spent fewer than 6.90 sedentary hours a day

Further analysis showed that men who reported high levels of sedentary behaviors and low levels of participation in recreational activities such as walking, jogging, and playing golf, were 41 percent more likely to experience colorectal adenoma recurrence compared with men who reported low levels of both sedentary behaviors and recreational activity. (ANI)

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