Protein links exercise to brain health: Research

Washington, Oct 12 (IANS) A protein, which increases during an endurance exercise, may promote brain health, US researchers say.

Researchers from the Dana-Farber Cancer Institute and Harvard Medical School found that the FNDC5 protein, when given to non-exercising mice, turned on genes that promote brain health and encourage growth of new nerves involved in learning and memory, Xinhua reported.

The findings, reported in the Cell Metabolism journal, explain the capacity of endurance exercise to improve cognitive function, particularly in older people.

If this protein can be developed into a drug, it might lead to improved therapies for cognitive decline in older people. It can slow the toll of neuro-degenerative diseases such as Alzheimer and Parkinson, according to the researchers.

Earlier, the researchers reported that the protein is produced by muscular exertion and is released into the bloodstream as a variant called irisin.

In the new study, they found that mice voluntarily running on a wheel for 30 days will have increased metabolic activity, which spurred a rise in FNDC5 protein.

The increase of FNDC5 in turn boosted the BDNF brain-health protein in the hippocampus, the researchers said.

Hippocampus is the part of the brain involved in learning and memory.

Having shown that FNDC5 is a molecular link between exercise and increased BDNF in the brain, the scientists looked into whether artificially increasing FNDC5 in the absence of exercise would have the same effect.

So, they used a harmless virus to deliver the protein to mice, hoping the FNDC5 could reach the brain and raise BDNF activity. Seven days later, they examined the mice brains and observed a significant increase in BDNF in the hippocampus.

However, the researchers said they are not sure whether the protein that got into the brain is FNDC5 itself or irisin or perhaps another variant of the protein.

Spiegelman added that further research is needed to determine whether giving FNDC5 actually improves cognitive function in other animals.

Matches

MORE TOP STORIES TODAY

Bowling worries for Super Kings

Bowling worries for Super Kings

After failing to defend a mammoth 205 against Kings XI Punjab, Chennai have a lot to think about. More »

Punjab pull off another big chase

Punjab pull off another big chase

GAME 7, SHARJAH—Maxwell, Miller, Pujara chase down Rajasthan's 192. More »

T20 test for Cheteshwar Pujara

T20 test for Cheteshwar Pujara

The class act from Saurashtra may have to rethink his approach to the mannerless format. More »

BCCI reputation lowest in 80 years: Manohar

BCCI reputation lowest in 80 years: Manohar

The former BCCI president says he was "disillusioned" by the happenings at the emergent working committee meeting on Sunday. More »

Special meeting to replace Srinivasan

Special meeting to replace Srinivasan

The BCCI is likely to convene a special general body meeting (SGM) in May to replace N Srinivasan on the board's disciplinary committee. More »

Shastri in proposed IPL probe panel

Shastri in proposed IPL probe panel

Some members stressed on the need for proposing names with an "impeccable record and clean image". More »

Roach escapes injury after car crash

Roach escapes injury after car crash

The West Indies fast bowler lost control of his BMW sedan due to slippery road conditions in his native Barbados on Saturday. More »

Repose faith in Indian coaches

Repose faith in Indian coaches

All of them cost plenty of dollars which I feel is unnecessary for a two- month tournament, says former cricketer Yajurvindra Singh. More »

Cook relieved after period in limbo

Cook relieved after period in limbo

The England captain is looking forward to a fresh start after a dispiriting Ashes defeat last year. More »

Panel can help clean mess: Raghavan

Panel can help clean mess: Raghavan

The former CBI Director is one of the three candidates proposed by the BCCI to head the enquiry into the IPL betting and spot-fixing scandal. More »

[INTERVIEW] Jayawardene and Sangakkara

[INTERVIEW] Jayawardene and Sangakkara

Mahela Jayawardene and Kumar Sangakkara go over their World T20 win, and feel grateful to have fans whose support remains unwavering in victory and de… More »

Need to improve fielding: Ashwin

Need to improve fielding: Ashwin

[T20 Newsline] Lacklustre Super Kings, fast-improving Sanju Samson and other news from IPL-7. More »

Aussie coach joins emerging Afghanistan

Aussie coach joins emerging Afghanistan

Peter Anderson has started work in Kabul as the fast-developing team prepare for their debut at next year's World Cup. More »

Chaos threatens to engulf SL again

Chaos threatens to engulf SL again

As Lanka's head coach decides to jump ship, euphoria over winning an ICC tournament has dissipated into fuistration. More »

Jayasuriya unhappy at Farbrace conduct

Jayasuriya unhappy at Farbrace conduct

Sri Lanka's chief selector is upset at news of head coach Paul Farbrace's possible move to England. More »

Have nothing to prove to anybody — Sehwag

Have nothing to prove to anybody — Sehwag

The Nawab of Najafgarh says a good run in IPL could help his chances of a comeback on India's tour to England in June. More »

Duminy steals first win for Delhi

Duminy steals first win for Delhi

Furious fifties by Duminy and Dinesh Karthik end a long losing streak for the Daredevils. More »

Five things England must do to bounce back

Five things England must do to bounce back

England have appointed a new head coach in Peter Moores. More »

AB, Parthiv seal Bangalore's second win

AB, Parthiv seal Bangalore's second win

Royal Challengers overcame a stutter to cruise to the small target they were set by Mumbai Indians. More »

‘Felt like helpless minority’

‘Felt like helpless minority’

Former BCCI treasurer Ajay Shirke says emotions got the better of Srinivasan and he tried to oversimplify things by calling Meiyappan an “enthusiast.” More »

Royal test for Kings

Royal test for Kings

Preview — Clash of philosophies between Australia-centric teams More »

No way back for Pietersen: ECB

No way back for Pietersen: ECB

Kevin Pietersen's hopes of reviving his international career appeared to end Saturday when ECB managing director Paul Downton said there was 'no way back'… More »

The world record that nearly wasn't

The world record that nearly wasn't

Twenty years ago this week, Brian Lara became Test cricket's highest scorer, but he almost didn't make it. More »

Srinivasan can attend BCCI meeting

Srinivasan can attend BCCI meeting

His status as president of TNCA makes him eligible to attend the Working Committee meeting on Sunday. More »