Washington, August 15 (ANI): Researchers have taken a step closer to reducing the risk of Alzheimer's disease by finding out how several variations in DNA sequence, which modify the disease, act.
Emerging evidence indicates that, much like in the case of high cholesterol, some Alzheimer's disease risk is inherited while the remainder is environmental. Family and twin studies suggest that about 70 percent of total Alzheimer's risk is hereditary.
UK Sanders-Brown Center on Aging researchers found that a 'protective' genetic variation near a gene called CD33 correlated strongly with how the CD33 mRNA was assembled in the human brain.
The authors found that a form of CD33 that lacked a critical functional domain correlates with reduced risk of Alzheimers disease. CD33 is thought to inhibit clearance of amyloid beta, a hallmark of Alzheimers disease.
The results obtained by the UK scientists indicate that inhibiting CD33 may reduce Alzheimer's risk.
A drug tested for acute myeloid leukemia targets CD33, suggesting the potential for treatments based on CD33 to mitigate the risk for Alzheimer's disease.
The research has been published in the Journal of Neuroscience. (ANI)