'Grow your own' hip replacement encourages real bone to re-grow

Washington, February 10 (ANI): A seven-year partnership between the University of Southampton and the University of Edinburgh has resulted in an artificial bone, created using stem cells and a new lightweight plastic, that could soon be used to heal shattered limbs.

The replacement inserted into broken bones encourages real bone to re-grow.

Researchers have developed the material with a honeycomb scaffold structure that allows blood to flow through it, enabling stem cells from the patient's bone marrow to attach to the material and grow new bone. Over time, the plastic slowly degrades as the implant is replaced by newly grown bone.

Scientists developed the material by blending three types of plastics. They used a pioneering technique to blend and test hundreds of combinations of plastics, to identify a blend that was robust, lightweight, and able to support bone stem cells. Successful results have been shown in the lab and in animal testing with the focus now moving towards human clinical evaluation.

"Fractures and bone loss due to trauma or disease are a significant clinical and socioeconomic problem. This collaboration between chemistry and medicine has identified unique candidate materials that support human bone stem cell growth and allow bone formation. Our collaborative strategy offers significant therapeutic implications," said Richard Oreffo, Professor of Musculoskeletal Science at the University of Southampton.

Professor Mark Bradley, of the University of Edinburgh's School of Chemistry, stated "We were able to make and look at a hundreds of candidate materials and rapidly whittle these down to one which is strong enough to replace bone and is also a suitable surface upon which to grow new bone.

"We are confident that this material could soon be helping to improve the quality of life for patients with severe bone injuries, and will help maintain the health of an ageing population," he added.

The study was published in the journal Advanced Functional Materials. (ANI)

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