Discovery of 'quadruple helix' DNA in human cells promises new therapies for cancer

London, January 21 (ANI): Cambridge researchers including an Indian origin have revealed that four-stranded 'quadruple helix' DNA structures - known as G-quadruplexes - also exist within the human genome.

They form in regions of DNA that are rich in the building block guanine, usually abbreviated to 'G'.

The findings mark the culmination of over 10 years investigation by scientists to show these complex structures in vivo - in living human cells - working from the hypothetical, through computational modelling to synthetic lab experiments and finally the identification in human cancer cells using fluorescent biomarkers.

The research goes on to show clear links between concentrations of four-stranded quadruplexes and the process of DNA replication, which is pivotal to cell division and production.

By targeting quadruplexes with synthetic molecules that trap and contain these DNA structures - preventing cells from replicating their DNA and consequently blocking cell division - scientists believe it may be possible to halt the runaway cell proliferation at the root of cancer.

"We are seeing links between trapping the quadruplexes with molecules and the ability to stop cells dividing, which is hugely exciting," said Professor Shankar Balasubramanian from the University of Cambridge's Department of Chemistry and Cambridge Research Institute, whose group produced the research.

"The research indicates that quadruplexes are more likely to occur in genes of cells that are rapidly dividing, such as cancer cells. For us, it strongly supports a new paradigm to be investigated - using these four-stranded structures as targets for personalised treatments in the future," he noted.

Physical studies over the last couple of decades had shown that quadruplex DNA can form in vitro - in the 'test tube', but the structure was considered to be a curiosity rather than a feature found in nature. The researchers now know for the first time that they actually form in the DNA of human cells.

"This research further highlights the potential for exploiting these unusual DNA structures to beat cancer - the next part of this pipeline is to figure out how to target them in tumour cells," said Dr Julie Sharp, senior science information manager at Cancer Research UK.

The study led by Giulia Biffi, a researcher in Balasubramaninan's lab at the Cambridge Research Institute, was published in Nature Chemistry. (ANI)

Matches

MORE TOP STORIES TODAY

On Now: Chennai Super Kings vs Delhi Daredevils

On Now: Chennai Super Kings vs Delhi Daredevils

IPL7, MATCH 8—Chennai bat. Hilfenhaus, Manhas, Ishwar in; Delhi unchanged. More »

Bowling worries for Super Kings

Bowling worries for Super Kings

After failing to defend a mammoth 205 against Kings XI Punjab, Chennai have a lot to think about. More »

T20 test for Cheteshwar Pujara

T20 test for Cheteshwar Pujara

The class act from Saurashtra may have to rethink his approach to the mannerless format. More »

Punjab pull off another big chase

Punjab pull off another big chase

GAME 7, SHARJAH—Maxwell, Miller, Pujara chase down Rajasthan's 192. More »

BCCI reputation lowest in 80 years: Manohar

BCCI reputation lowest in 80 years: Manohar

The former BCCI president says he was "disillusioned" by the happenings at the emergent working committee meeting on Sunday. More »

Special meeting to replace Srinivasan

Special meeting to replace Srinivasan

The BCCI is likely to convene a special general body meeting (SGM) in May to replace N Srinivasan on the board's disciplinary committee. More »

Shastri in proposed IPL probe panel

Shastri in proposed IPL probe panel

Some members stressed on the need for proposing names with an "impeccable record and clean image". More »

Roach escapes injury after car crash

Roach escapes injury after car crash

The West Indies fast bowler lost control of his BMW sedan due to slippery road conditions in his native Barbados on Saturday. More »

Repose faith in Indian coaches

Repose faith in Indian coaches

All of them cost plenty of dollars which I feel is unnecessary for a two- month tournament, says former cricketer Yajurvindra Singh. More »

Panel can help clean mess: Raghavan

Panel can help clean mess: Raghavan

The former CBI Director is one of the three candidates proposed by the BCCI to head the enquiry into the IPL betting and spot-fixing scandal. More »

Cook relieved after period in limbo

Cook relieved after period in limbo

The England captain is looking forward to a fresh start after a dispiriting Ashes defeat last year. More »

[INTERVIEW] Jayawardene and Sangakkara

[INTERVIEW] Jayawardene and Sangakkara

Mahela Jayawardene and Kumar Sangakkara go over their World T20 win, and feel grateful to have fans whose support remains unwavering in victory and de… More »

Need to improve fielding: Ashwin

Need to improve fielding: Ashwin

[T20 Newsline] Lacklustre Super Kings, fast-improving Sanju Samson and other news from IPL-7. More »

Aussie coach joins emerging Afghanistan

Aussie coach joins emerging Afghanistan

Peter Anderson has started work in Kabul as the fast-developing team prepare for their debut at next year's World Cup. More »

Chaos threatens to engulf SL again

Chaos threatens to engulf SL again

As Lanka's head coach decides to jump ship, euphoria over winning an ICC tournament has dissipated into fuistration. More »

Jayasuriya unhappy at Farbrace conduct

Jayasuriya unhappy at Farbrace conduct

Sri Lanka's chief selector is upset at news of head coach Paul Farbrace's possible move to England. More »

Have nothing to prove to anybody — Sehwag

Have nothing to prove to anybody — Sehwag

The Nawab of Najafgarh says a good run in IPL could help his chances of a comeback on India's tour to England in June. More »

Duminy steals first win for Delhi

Duminy steals first win for Delhi

Furious fifties by Duminy and Dinesh Karthik end a long losing streak for the Daredevils. More »

Five things England must do to bounce back

Five things England must do to bounce back

England have appointed a new head coach in Peter Moores. More »

AB, Parthiv seal Bangalore's second win

AB, Parthiv seal Bangalore's second win

Royal Challengers overcame a stutter to cruise to the small target they were set by Mumbai Indians. More »

‘Felt like helpless minority’

‘Felt like helpless minority’

Former BCCI treasurer Ajay Shirke says emotions got the better of Srinivasan and he tried to oversimplify things by calling Meiyappan an “enthusiast.” More »

Royal test for Kings

Royal test for Kings

Preview — Clash of philosophies between Australia-centric teams More »

No way back for Pietersen: ECB

No way back for Pietersen: ECB

Kevin Pietersen's hopes of reviving his international career appeared to end Saturday when ECB managing director Paul Downton said there was 'no way back'… More »

The world record that nearly wasn't

The world record that nearly wasn't

Twenty years ago this week, Brian Lara became Test cricket's highest scorer, but he almost didn't make it. More »