England captain Eoin Morgan hit 107 as his team made 296 for six batting first against the West Indies in the first one-day international at the Sir Vivian Richards Stadium in Antigua on Friday.
It was Morgan's 10th ODI century.
Opener Sam Billings contributed 52 while all-rounder Ben Stokes smashed 55.
Friday's game is the first of three matches.
The second will also take place at North Sound on Sunday before switching to Barbados on March 9.