A talented wicket-keeper, Mangaliso Mosehele started playing cricket in 1998 and was a part of the provincial schools team. He was selected to represent the South African Under-19 team for the 2008 World Cup. He forms a part of the lower-middle order. He started his first-class career with the Easterns in 2008. Mosehle also plies his trade for the Titans and was included in their T20 squad for the 2012 Champions League T20.